Associate Professor | Department of Botany
Contact (Off.): +91-11-27667458
Email Address : archanasingh[at]hrc[dot]du[dot]ac[dot]in
Dr. Archana Singh, M.Sc, Ph.D, is a Plant Molecular Biologist at Hansraj College, University of Delhi. She graduated from Miranda House, University of Delhi, and obtained her Masters from Department of Botany, University of Delhi. Dr. Archana obtained her Ph.D. in Plant Molecular Biology from National Institute for Plant Genome Research, Aruna Asaf Ali Marg, New Delhi. She has been teaching theory and practical classes of Bioinformatics, Analytical Techniques in Plant Sciences, Cell Biology, Molecular Biology and Biotechnology to undergraduate students of B.Sc (Hons) Botany and B.Sc (Prog) Life Sciences, since 2009. Her research domains include Functional Genomics in the area of Plant Protection and Human Health. Dr. Archana worked on “Moleular Analysis of early-responsive genes of Chickpea during biotic stresses” for her doctoral research. Dr. Singh is a recipient of IOE Fellow, IOE, DU (2022); EMBO Fellowship (2019) by European Molecular Biology Organization, Heidelberg, Germany; SERB-Early Career Research Award (2018); UGC-Raman post-doctoral fellowship (2016-2017); DST-Young Scientist Award (Fasttrack, 2012) from Ministry of Science of Technology, Govt. of India. Dr. Singh has published more than forty research articles in various journals of National and International repute such as Critical Reviews in Biotechnology, Journal of Experimental Botany (Oxford), Journal of Integrated Plant Biology (Wiley), Frontiers in Plant Sciences, Journal of Biotechnology,Scientific reports, International Journal of Biological Macromolecules, BBA-Molecular basis of Disease etc. Dr. Singh, has also edited two books and authored more than ten book chapters that are published by Springer Nature and Elsevier. In addition, she has been awarded with International Travel grants from DBT and DST. Dr. Archana has undertaken five research projects funded by various external agencies and two from University of Delhi. Dr. Singh has worked as visiting scientist at Department of Plant Pathology, University of Kentucky, Lexington, USA and also at Department of Molecular Ecology, Max Planck Institute of Chemical Ecology, Jena, Germany. Currently Dr. Singh is supervising one post-doctoral fellow (NPDF), two Ph.D. scholars and few JRFs and summer interns.
Currently, Dr. Archana's research focusses on:
Her research outcomes has been recognised by scientific community. It was a proud moment, when one of the research articles published from this lab entitled “Pathogenesis Related Proteins: a defensin for plants but an allergen for humans” was highlighted in the news report of famous Current Science Journal (Current Science Report, News, Vol. 119, No. 5, 10th September 2020) and an article entitled “Protease inhibitors: recent advancement in its usage as a potential biocontrol agent for insect pest management” published in Insect Science was selected as top cited paper by Wiley.
Dr. Archana has also shown potential participation in multi-institutional collaborative work that led to publications, development of a database and patents. Dr. Archana in collaboration with other colleagues from different institutes, has developed a method for identifying multidrug resistant, Mycobacterium tuberculosisstrain. Dr. Archana was a team member in the development of a very useful tool, NeuroPIpred (https://webs.iiitd.edu.in/raghava/neuropipred/team.php).
Group Leader & Project Investigator: Dr. Archana Singh, IOE Fellow, MRSB, EMBO Fellow, Raman Fellow, Associate professor, Department of Botany
Post-Doctoral Fellow: Dr. Sujata Singh
Ph. D. Scholars: Ms. Manisha Yadav
Ms. Ruby Panwar
SERB-JRF: Ms. Jyotsna Pandey
Interns: Ms. Mohini Kajila
M.Sc. Intern: Mr. Rahul Arora
Ms. Mansi Taneja
B. Tech Interns: Ms. Kriti Singh
Currently, five research projects are being undertaken:
The group primarily works on molecular aspects of early defense signaling events to decipher components of calcium signaling during soybean-Spodoptera litura interaction. The group is also elucidating the Mitogen-activated protein kinase pathway involved in plant defense to counter pest and pathogen attack.Members of the group are also involved in studying defense orchestration of maize in response to Spodoptera litura, a voracious Noctuidae pest. In order to understand the molecular mechanism behind maize tolerance against S. litura, transcriptomics and proteomics studies were performed and the results indicated a balance of growth and defense response and utilization of a highly evolved C-diversion response was noticed. Maize showed better tolerance against herbivory and maintained its fitness using a combinatorial strategy.
The group has contributed in the area of Human Health and drug discovery as well. The group as an collaborative effort, has investigated on naturally occurring anti-cancerous compounds using in silico and in vitro tools and techniques to develop inhibitor of receptor tyrosine kinase-like orphan receptor ; identification of novel inhibitors of aldo‐ketoreductase 1C1 as potential lead molecules in treatment of breast cancer; application of myeloid cell leukemia 1 in cancer therapy. Recently, the group also published few articles on COVID-19, that are very significant and highly cited. The group works on potential plant allergenic proteins, which will allow the users to make an informed decision about the consumption of food with high degree of allergenic proteins. It was a proud moment, when one of the research articles published from this lab entitled “Pathogenesis Related Proteins: a defensin for plants but an allergen for humans” was highlighted in the news report of famous Current Science Journal (Current Science Report, News, Vol. 119, No. 5, 10th September 2020).
The group has also shown potential participation in multi-institutional collaborative work that led to publications, development of a database and patents. Dr. Archana in collaboration with other colleagues from different institutes, has developed a method for identifying multidrug resistant, Mycobacterium tuberculosisstrain. Dr. Archana was a team member in the development of a very useful tool, NeuroPIpred (https://webs.iiitd.edu.in/raghava/neuropipred/team.php).
Ph. D. Thesis title: “Moleular Analysis of early-responsive genes of Chickpea during biotic stresses”
Degree Awarded: 2009
Extramural Research Grant Awarded:
2022-25 Funded by SERB, Ministry of Science & Technology, Govt. of India “Deciphering the MAPK Pathway in Glycine max during Spodoptera litura – infestation” (PI)
2022-23 Funded by Hansraj College, ““Identification of potential allergenic proteins from Tomato” (PI)
2020-2022 Funded by SERB, Ministry of Science & Technology, Govt. of India " Proteomic analysis of herbivory induced defense response in Zea mays upon Spodoptera litura infestation " (Mentor / PI)
2018-2022 Funded by SERB, Ministry of Science & Technology, Govt. of India " Functional analysis of Spodoptera litura-inducible calmodulin-like protein from Glycine max” [PI]
2019 Funded by EMBO, Meyerhofstrasse Heidelberg, Germany " A Quantitative Trait Loci Mapping study to detect variation in JA signaling in the MAGIC population of Nicotiana attenuata " (CoPI)
2016-2017 Funded by UGC, Govt. of India " Identification of G3P-dependent proteins and deciphering their role in plant systemic immunity " (CoPI)
2013-2016 Funded by SERB, Ministry of Science & Technology, Govt. of India, “Cloning and functional characterization of Helicoverpa -inducible hevein-like protein from chickpea″ [PI]
2015-2016 Funded by UGC/DU " Comprehension of ethnic practices of selected Indian tribes as pro-ecological customs and their deviation from the stream " (CoPI)
2013-2014 Funded by SERB, DST " Critical and Scientific analysis on use of alternative medicines with practical approach and case studies” [PI]
(Selected) Book Chapters Authored
Publications in Conference Proceedings / Presentations
Invited Talks Delivered/Expert Panel on FM Radio:
Trainings/workshop/ Symposium Participated / Attended:
Awards and Honors:
Association with Professional Bodies
Invited to review research articles of the following international journals: